Osaka University Professor Sakaguchi Wins Nobel Prize

As of 3 p.m. on October 6th, Typhoon No. 22 (Halong) was moving northwest over the ocean near the Ogasawara Islands. The typhoon has intensified to form a storm zone with sustained winds exceeding 25 meters per second. Depending on its course, the typhoon may bring strong winds and heavy rain to areas along the Pacific coast from western to eastern Japan. Particularly heavy rainfall is expected across the Tokai and Kanto coastal regions, as well as the Izu Islands. Authorities are urging residents to stay alert for further updates.

In other news, Osaka University’s specially appointed professor, Shimon Sakaguchi, has been awarded this year’s Nobel Prize in Physiology or Medicine for his groundbreaking work in immunology. Sakaguchi is best known for discovering regulatory T cells, a type of immune cell that suppresses excessive immune responses. His findings have had far-reaching implications in medical science.

On the night of October 5th, a collision occurred on the Tokyu Den-en-toshi Line in Kawasaki City. A local train attempting to arrive at Kajigaya Station struck a stationary out-of-service train, causing several cars of the latter to derail. Investigators from the Japan Transport Safety Board arrived at the scene on the morning of October 6th to begin examining the cause of the accident.

Meanwhile, a Spanish tourist was attacked by a bear while visiting Shirakawa-go, the UNESCO World Heritage village in Gifu Prefecture known for its traditional thatched-roof houses, on October 5th. This incident adds to a growing number of bear encounters reported across Japan in recent weeks.

In political news, Sanae Takaichi was elected as the Liberal Democratic Party’s new president on October 4th. After defeating agriculture minister Shinjiro Koizumi in a runoff, she became the party’s first female leader. On stage, Takaichi declared, “I ask everybody to work like a horse,” signaling her call for dedicated effort from party members.
https://newsonjapan.com/article/147170.php

If Iran restarts nuclear program, we will deal with that too, Trump warns

Trump Warns: “If Iran Restarts Nuclear Program, We Will Deal With That Too”

US President Donald Trump issued a stern warning regarding Iran’s nuclear ambitions during a speech at Naval Station Norfolk, Virginia. The event commemorated the 250th anniversary of the US Navy.

Speaking at the Navy 250 Celebration in Norfolk on October 5, 2025, Trump emphasized that if Iran restarts its nuclear program, the United States is prepared to address the challenge decisively.

First Lady Melania Trump was also present, applauding as the president spoke.

Photo credit: REUTERS/JONATHAN ERNST

By Jerusalem Post Staff, Maariv, REUTERS

https://www.jpost.com/middle-east/iran-news/article-869560

The AI threat

**The Hidden Harms of Artificial General Intelligence: A Call for Awareness and Action**

*“The people who shut their eyes to reality simply invite their own destruction; anyone who insists on remaining in a state of innocence long after that innocence is dead turns himself into a monster.”*
— James Baldwin

The sudden rise of artificial general intelligence (AGI), particularly in the form of large language models (LLMs), has sparked widespread debate about the potential benefits and harms these technologies may bring. While many focus on their usefulness, I argue that the possible harms are not yet fully understood—especially by the general public.

We are already witnessing an increasing number of AI-related disasters, notably affecting human intellect and self-expression. A research paper from Cornell University titled *Your Brain on ChatGPT* warns that unregulated use of these tools could stunt the development of human intelligence. In particular, it may diminish critical thinking skills on a mass scale.

Large corporations and political elites stand to gain significantly from an uninformed populace that accepts simplified narratives designed to advance their agendas. The easiest way to achieve this indoctrination is through biased programming of chatbots, subtly shaping opinions and suppressing dissent.

### The Hidden Costs of AI

The price we pay for these conveniences extends far beyond cognitive impairment. It includes severe environmental risks, democratic erosion, and exploitation of public resources.

Karen Hao, American journalist and author of *Empire of AI*, explores these issues in her deeply researched work. She highlights how some companies’ unchecked use of natural resources for generative AI development is depleting freshwater and arable land. These companies, she argues, behave like techno-authoritarians, disregarding democratic principles by failing to consult affected communities about the environmental damage caused by their data centers.

The Environmental and Energy Study Institute (EESI) estimates that a single data center can consume up to five million gallons of water per day—equivalent to the daily water usage of a town with 10,000 to 50,000 residents. An Indiana-based non-profit, the Citizen Action Coalition, reveals that AI corporations often use shell companies or secret project code names to conceal their plans for new data centers until after local approvals are secured.

The Hoosier Environmental Council describes generative AI data centers as “hyperscale” facilities that demand vast amounts of water and energy, and these data centers are rapidly expanding. This growth forewarns further exploitation of public resources and labor, along with a likely exponential increase in carbon emissions.

Sourabh Mehta’s article *How Much Energy Do LLMs Consume? Unveiling the Power Behind AI* for the Association of Data Scientists delves deeper into the enormous energy footprint of these models.

### Misconceptions and Corporate Narratives

In an interview with Harvard Business School’s Institute for Business in Global Society, Vercept co-founder Oren Etzioni addressed some myths surrounding AI. He suggested that fears of AI’s harm stem mainly from misinformation, not tangible threats, and advised people to learn to use AI more efficiently to avoid being left behind.

However, such optimistic assertions fall short when CEOs who profit from this technology portray it simply as a productivity booster. Etzioni’s claim that people confuse fiction with reality—treating AI as if it is on a path to sentience—is fundamentally flawed.

Chatbots today are not under fire because they resemble Harlan Ellison’s 1967 antagonist AM, a sentient AI bent on human suffering. Rather, criticism arises from their proven intellectual unreliability and their detrimental effects on users’ cognitive abilities, income equality, privacy, and data ownership.

### The Way Forward: Resistance and Collective Action

So, how do we keep pace with this rapidly evolving landscape while safeguarding our autonomy?

**First, individual resistance.** This means consciously choosing to exercise your own intellect and reasoning, rather than relying on chatbots to do the heavy lifting. Resist the dopamine-driven distractions of mind-numbing social media. Instead, invest time in reading the classics—works by Homer, Goethe, Lermontov, Thucydides, Milton, Stendhal, Cellini, and others—to strengthen focus, cognition, and literacy.

Let’s be clear: chatbots are merely predictive algorithms. Their “intelligence” depends entirely on the data they consume. They do not possess original thought—a faculty uniquely human. Even generative AI models, as explained by the International Business Machines Corporation (IBM), generate content by training on massive datasets. IBM itself is focused on integrating AI into modern business platforms, not creating sentient machines.

**Second, collective action.** Self-preservation on a larger scale is more challenging, requiring resolve and resilience. But collective efforts empower the public to influence how AI technologies are adopted, and to what extent they operate.

Through collective action, we can demand protections for civil liberties and human rights, both intellectual and labor-related. As AI becomes more integrated into society, we must advocate for universal rights and safety measures in an AI-operated world.

### Conclusion

We stand at the cusp of a new era. It is imperative that we confront the realities of artificial intelligence honestly and actively engage in shaping its future. By balancing personal responsibility with collective advocacy, we can harness the benefits of AI while minimizing its risks—ensuring that technology serves humanity, not the other way around.
https://www.thenews.com.pk/tns/detail/1348325-the-ai-threat

Fujitsu and Nvidia Expand Partnership to Accelerate AI Implementation

Tokyo University of Technology unveiled its new supercomputer, named Seiran, on October 2nd, marking the start of full-scale operations. Equipped with the latest GPUs from U.S. chipmaker Nvidia, the system is designed specifically for generative AI and stands as the largest of its kind among Japan’s private universities.

In other news, Fujitsu and U.S. semiconductor giant Nvidia have announced plans to expand their collaboration in the field of artificial intelligence. Their joint efforts aim to accelerate the practical use of AI across various industries, driving innovation and efficiency.

A new form of cyberattack, known as “Clickfix,” is rapidly spreading by exploiting the familiar pop-up that asks users to confirm they are not robots. First detected in 2024, this attack has expanded quickly through 2025, prompting police in Tokyo and Aichi Prefecture to issue urgent warnings to the public.

Provably fair gaming has quickly become one of the most pivotal factors players look for when gaming on crypto-based platforms. This technology ensures transparency and trust, making it increasingly important in the digital gaming world.

OpenAI has unveiled its latest video generation AI, Sora2, capable of producing realistic footage in about three minutes. The system can create a wide range of content, including Japanese anime-style clips and composite videos featuring real individuals, opening new possibilities in video production.

A recent survey released by Meiji Yasuda Life Insurance revealed that more than 60 percent of parents with young children expressed interest in using artificial intelligence to support childcare. This highlights the growing acceptance and potential of AI technologies in daily family life.

Meanwhile, with the rapid development of the cryptocurrency market, Wall Street tycoons are flocking to the space, increasing competition. As a result, retail investors are facing unprecedented pressure in this evolving financial landscape.
https://newsonjapan.com/article/147141.php

Reporter’s Notebook: Jane Goodall’s legacy

Jane Goodall’s groundbreaking work broke down the wall between man and nature, reshaping our understanding of the natural world.

Her legacy will live longer than she could have ever imagined when she first walked into the forest.

As “CBS Evening News” co-anchor John Dickerson explains, Goodall’s contributions continue to inspire and influence generations around the globe.
https://www.cbsnews.com/video/reporters-notebook-jane-goodalls-legacy/

Reporter’s Notebook: Jane Goodall’s legacy

Jane Goodall’s work broke down the wall between man and nature. Her groundbreaking research transformed our understanding of the natural world and our place within it.

When she first walked into the forest, she could hardly have imagined the profound legacy she would leave behind. Today, her contributions continue to inspire and influence generations of scientists, conservationists, and nature lovers worldwide.

As “CBS Evening News” co-anchor John Dickerson explains, Jane Goodall’s impact extends far beyond her initial discoveries, creating a lasting bond between humanity and the environment.
https://www.cbsnews.com/video/reporters-notebook-jane-goodalls-legacy/

Famous Primatologist Jane Goodall Dead at 91 — The ‘Voice for Animals’ Is Remembered for ‘Protecting the Natural World’

**Jane Goodall, Renowned Primatologist and Conservationist, Dies at 91**

*Published October 1, 2025, 2:26 p.m. ET*

Jane Goodall, best known for her groundbreaking research and tireless efforts to protect chimpanzees, has passed away at the age of 91, RadarOnline.com can reveal. The esteemed animal welfare activist remained active into her 90s and was in California this week as part of her ongoing speaking tour.

**Institute Confirms Passing**

The Jane Goodall Institute announced this morning, Wednesday, October 1, 2025, that Dr. Jane Goodall DBE, UN Messenger of Peace and Founder of the Jane Goodall Institute, has died of natural causes.

“She was in California as part of her speaking tour in the United States,” the Institute’s statement read.

The announcement continued: “Dr. Goodall’s discoveries as an ethologist revolutionized science, and she was a tireless advocate for the protection and restoration of our natural world.”

**Global Tributes Pour In**

Social media users quickly responded to the news of Goodall’s passing. One user wrote, “Rest in peace, Jane Goodall. You taught us that kindness is a form of strength and that respect for life in all its forms is the truest measure of humanity. You will be dearly missed.”

Another added, “It is impossible to sum up the impact she has had on our world and on science in a social media post. She lived a long and incredible life, but I am devastated.”

“A pioneer, a dreamer, a voice for animals and the planet,” praised another. “She taught us to see ourselves in chimpanzees and hope in nature, and the world feels less friendly without her.”

**A Lifetime of Groundbreaking Work**

Jane Goodall founded the Jane Goodall Institute in 1977 to support research on great apes. In addition to her scientific work, she established Roots & Shoots, a youth program dedicated to environmental and humanitarian issues, as well as TACARE, which focuses on sustainable development in African villages.

She began her landmark chimpanzee research in the wild in Tanzania at just 26 years old, making discoveries that forever changed the field of ethology.

Through her research, Goodall demonstrated that primates exhibit behaviors strikingly similar to humans, including complex communication and even the use of tools.

In a 2020 interview with ABC News, she described primates’ behavior:

*“Their behavior, with their gestures, kissing, embracing, holding hands, and patting on the back… The fact that they can actually be violent and brutal and have a kind of war, but also loving and altruistic.”*

**Inspiring Women in STEM**

Goodall’s dedication has also inspired generations of women to pursue careers in STEM (science, technology, engineering, and math). According to The Jane Goodall Institute — which cited census data from 1970 to 2011 — the number of women in STEM fields has risen from 7 percent to 26 percent in the last 60 years.

**A Call to Action on Climate Change**

Beyond her work with animals, Goodall was a passionate advocate for addressing the climate crisis. She often emphasized the urgent need for human action.

“We are definitely at a point where we need to make something happen. We are imperiled. We have a window of time. I’m fairly sure we do. But, we’ve got to take action,” she said.

**Cherished Support from Family**

Despite facing skepticism during her lifetime, Goodall always had unwavering support from her mother.

“She said, if you really want to do something like this, you’re going to have to work really hard,” Goodall recalled during an interview on the *Call Her Daddy* podcast with host Alex Cooper.

“Take advantage of every opportunity. And if you don’t give up, hopefully you find a way.”

Reflecting on her legacy, Goodall added, “I wish Mom was alive, and maybe she’s listening. The number of people who said, ‘Jane, I want to thank you. You’ve taught me because you did it. I can do it too.’”

Jane Goodall’s extraordinary life and legacy continue to inspire millions worldwide to respect, protect, and cherish the natural world. She will be deeply missed.
https://radaronline.com/p/jane-goodall-dead-animal-welfare-activist-monkeys-chimps/

What is lecanemab, the newly approved Alzheimer’s drug? Can it really slow down dementia

New Alzheimer’s Drug Lecanemab Approved in Australia: What You Need to Know

Dementia is a condition characterized by progressive memory and thinking problems. It is now the most common cause of death in Australia. While there are many causes of dementia, Alzheimer’s disease accounts for about 60% to 80% of all cases.

Last week, Australia’s Therapeutic Goods Administration (TGA) approved a new drug for early Alzheimer’s disease: lecanemab, sold under the brand name Leqembi. This approval follows that of a similar drug, donanemab, earlier this year. Although lecanemab has been shown to slow disease progression in some people diagnosed early, its high cost may put it out of reach for many Australians.

How Does Lecanemab Work?

Lecanemab belongs to a class of drugs known as monoclonal antibodies. When our bodies face foreign invaders such as bacteria or viruses, the immune system produces antibodies—proteins that bind to the invader and mark it for destruction by immune cells.

A monoclonal antibody like lecanemab is produced in a laboratory to target a specific substance—in this case, the amyloid protein. Amyloid plaques are a microscopic hallmark of Alzheimer’s disease. By binding to amyloid, lecanemab helps the immune system to remove this protein from the brain, thereby limiting ongoing damage.

How Effective Is Lecanemab?

The TGA’s approval is based on a large clinical trial involving 1,734 participants over 18 months, funded by Eisai, the drug company. All participants had positron emission tomography (PET) scans confirming the presence of amyloid in their brains before the trial.

Results showed that patients with early Alzheimer’s or mild cognitive impairment due to early Alzheimer’s who received lecanemab experienced 27% less disease progression compared to those given a placebo over 18 months. This was measured using the Clinical Dementia Rating Sum of Boxes scale, which assesses both cognition and function. This slowing of decline equates to about five months less deterioration in those treated with lecanemab.

For patients continuing treatment, evidence suggests benefits may persist for up to four years. Participants also showed substantial reductions in amyloid levels as seen on PET scans. By the end of the trial, most participants were below the threshold indicating Alzheimer’s presence, although their symptoms were not reversed.

What Are the Side Effects?

Safety concerns have been raised by regulators. The TGA initially rejected lecanemab’s approval last year based on its risk-benefit profile. In the clinical trial, 12.6% of patients receiving lecanemab experienced brain swelling. This rate increased to 32.6% in individuals carrying two copies of the apolipoprotein E4 (ApoE4) gene, which promotes Alzheimer’s.

Among those with brain swelling, 22% experienced side effects such as headaches, dizziness, blurred vision, and balance problems. Most side effects were mild. However, a small number of participants on blood-thinning medications suffered serious brain bleeds, some of which were fatal.

The remaining 78% with brain swelling showed no symptoms. Due to these risks, patients on lecanemab require MRI brain scans every three months for monitoring.

Furthermore, 17.3% of patients treated with lecanemab experienced small brain bleeds (microhemorrhages), compared to 9.0% in the placebo group.

Following the initial rejection, the TGA appeal included new safety and efficacy data covering up to four years of treatment.

How Much Does Lecanemab Cost?

Lecanemab is not currently subsidized by Australia’s Pharmaceutical Benefits Scheme (PBS). The drug costs approximately A$40,000 per year, making it unaffordable for many potential patients.

The recommended dosing schedule consists of fortnightly infusions for an 18-month period, followed by monthly maintenance doses. Additional costs include required monitoring such as doctor visits, MRI, and PET scans.

As of now, the Pharmaceutical Benefits Advisory Committee (PBAC) has not yet reviewed lecanemab for PBS listing. The committee recently rejected a similar drug, donanemab, in July due to concerns about limited and uncertain benefits relative to treatment burdens.

Lecanemab and donanemab share similar mechanisms, efficacy, risk profiles, and costs.

Bottom Line

Lecanemab is approved only for early-stage Alzheimer’s disease. If you or a loved one experience early signs—such as consistent short-term memory loss or confusion about dates—it is important to seek medical advice promptly. Early diagnosis is essential to explore available treatment options.

It is important to understand that neither lecanemab nor donanemab cures Alzheimer’s disease. These drugs may slow disease progression but do not improve existing symptoms.

Additionally, lecanemab is not effective for dementia caused by conditions other than Alzheimer’s, nor for individuals with advanced stages of Alzheimer’s disease.

https://knowridge.com/2025/10/what-is-lecanemab-the-newly-approved-alzheimers-drug-can-it-really-slow-down-dementia/

Magnitude 6.9 earthquake strikes Eastern Visayas region, Philippines; no tsunami warning

Magnitude 6.9 Earthquake Strikes Eastern Visayas Region, Philippines; No Tsunami Warning

A 6.9-magnitude earthquake struck near the Eastern Visayas region in the Philippines, according to the United States Geological Survey (USGS). The quake was shallow, raising initial concerns about possible tsunami threats.

Authorities have reported that there is no tsunami warning following the earthquake, providing some relief to residents in the affected areas.

A man inspects a damaged building and car in the aftermath of the earthquake in the Philippines, July 28, 2022. (Photo Credit: REUTERS/LISA MARIE DAVID)

Officials continue to assess the situation to determine the full extent of the damage and to ensure the safety of local communities.

https://www.jpost.com/environment-and-climate-change/article-869118